High Dose Melatonin
Melatonin is a hormone produced by the pineal gland in our brain, with neurotransmitter modulatory activity. Most of us are aware that melatonin is responsible for promoting sleep, but most are unaware that melatonin can directly kill many different types of cancer cells. It is a naturally produced cytotoxin, which can induce tumor cell death (apoptosis). In instances where the tumor has already established itself in the body, melatonin has been shown to inhibit the tumor’s growth rate. Melatonin exhibits natural oncostatic activity and inhibits cancer cell growth. In patients in whom cancer already has become a noticeable physical burden and produces overt symptoms, melatonin has been shown to alleviate numerous cancer symptoms and to inhibit development of new tumor blood vessels (tumor angiogenesis), which in turn inhibits the cancer from spreading further (metastasis). Melatonin can retard tumor metabolism and development by lowering the body temperature; it is a natural inducer of hypothermia. Furthermore, as an inducer of antioxidants and itself a weak preventive antioxidant, melatonin hinders tumor cells from participating in free radical damage to normal cells and consequently limits oxidative damage to DNA, lipids, amino acids, and proteins.
Summary of Studies Using Melatonin
Lissoni’s Phase II Randomized Clinical Trial Results |
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One-Year Survival |
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Tumor Type |
Patient Number |
Basic Therapy |
Melatonin Dose |
Melatonin |
Placebo |
Level Of Significance |
Metastatic Non- Small-Cell Lung |
100 |
Chemotherapy |
20 mg |
5-year survival 6% |
5-year survival 0% |
N/A |
Metastatic Non- Small-Cell Lung |
63 |
Supportive Care Only |
10 mg |
5-year survival 6% |
Under 1% |
<0.05 |
Glioblastoma |
30 |
Conventional Radiotherapy |
10 mg |
43% |
Under 1% |
<0.05 |
Metastatic Breast |
14 |
Tamoxifen |
20 mg |
64% |
36% |
<0.01 |
Brain Metastases |
50 |
Conventional Radiotherapy |
20 mg |
38% |
12% |
<0.05 |
Metastatic Colorecta |
50 |
IL-2 |
40 mg |
36% |
12% |
<0.05<0.05 |
Metastatic Non- Small-Cell Lung |
60 |
IL-2 |
40 mg |
24% |
19% |
<0.05 |